Use of Niacin Combinations With Statins – Results on Risks in Obesity

Here is another failed lipid lowering study. The focus was the use of niacin combinations with statins.

Finding was worse outcomes with niacin added. But, our old enemy OxLDL was specifically associated with progressive valvular disease. OxLDL are not plain LDL but oxidized version that are removed from the blood stream by endothelial cells as toxins but then lead to vascular inflammation in the atherosclerotic cascade. OxLDL can be encouraged by polyunsaturated fats and inflammatory conditions in the body…consistent with the associations of diabetes, rheumatologic conditions and other diseases increasing CAD risk. OxLDL can be prevented by appropriate diet and some herbal substances like CBD.

“Abnormal lipid measures were associated with structural degeneration of bioprosthetic aortic valves in a single-center study reported in Heart. The only independent predictor for valve degeneration, which occurred in 21% of patients by 8 years, was the ratio of oxidized low-density lipoprotein (OxLDL) to HDL (odds ratio 1.49). Elevation of that measure and of PCSK9 (induced by OxLDL) together were tied to an almost three-fold increase of structural valve degeneration risk (odds ratio 2.93). “
[comment: PCSK9 damages LDL receptors that remove LDL cholesterol from the blood. Thus, oxLDL damages the arteries and the liver]

What about CBD?
Activation of GPR55 Receptors Exacerbates oxLDL-Induced Lipid Accumulation and Inflammatory Responses, while Reducing Cholesterol Efflux from Human Macrophages.
[Cannabidiol blocks GPR55]

Cannabidiol-2′,6′-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro.
[15-lipoxygenase LDL is oxLDL]

Therefore, CBD could prevent atherosclerosis, heart disease and liver disease with these mechanisms. CBD is a homeostasis substance that restores balance and health without any significant adverse effects, toxicity or drug interactions. What amount? Everyone is different but 30mg of high quality, organic CBD from hemp is suggested.

Medpage: More Bad News on Niacin; Mixed Results on Risks in Obesity; Lipids vs. Valves

Leave a Reply

Your email address will not be published. Required fields are marked *