84 individuals with obesity and type 2 diabetes were randomized to a low-carb, ketogenic diet or a calorie restricted low-glycemic diet. The study went on for 24 weeks.
Weight Loss: The low-carb group lost more weight (11.1 kg – 24.4 lbs) compared to the low-glycemic group (6.9 kg – 15.2 lbs).
Conclusion: The low-carb group lost significantly more weight than the low-glycemic group. There were several other important differences:
- Hemoglobin A1c went down by 1.5% in the LC group, compared to 0.5% in the low-glycemic group.
- HDL cholesterol increased in the LC group only, by 5.6 mg/dL.
- Diabetes medications were either reduced or eliminated in 95.2% of the LC group, compared to 62% in the low-glycemic group.
- Many other health markers like blood pressure and triglycerides improved in both groups, but the difference between groups was not statistically significant.
Westman EC, et al. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutrion & Metabolism (London), 2008.